Automating the design and production of customised face masks for children with facial differences who need breathing support

Developing a cutting-edge treatment for a severe form of epilepsy that affects children

Krabbe disease: developing a potential new drug treatment for a rare and severe condition that affects children

NMDAR-antibody encephalitis: using cutting-edge brain scanning techniques to personalise treatment for a rare brain disease

Primary ciliary dyskinesia: searching for drugs to treat this debilitating, rare lung condition

Developing a new gene therapy for babies born with a rare severe lung condition

Improving the treatment of traumatic brain injuries

Long COVID: understanding how COVID-19 affects the brains of children with persistent symptoms

Developing a new treatment for high-risk brain cancer in children

Multiple sclerosis: assessing nerve repair in children to find out if they could benefit from new treatments

Hunter syndrome: improving gene therapy for this rare and devastating disease

Vici syndrome: searching for drug treatments for this rare and severe inherited condition

Developing a diagnostic device that could be used to screen newborn babies for an infection that can cause long-term health problems

Developing a new gene therapy for children with a rare severe liver disease

Can pregnancy measurements help predict which babies are most at risk of learning difficulties?

Asthma: predicting which pre-school children with wheezing will go on to develop the condition later in childhood

Cerebral palsy: improving the understanding of the causes of foot deformity to help alleviate pain and improve mobility

Sickle cell disease: could an asthma medicine improve children’s intellectual abilities?

Brain injury at birth: could a new treatment called mitochondrial transplantation help protect brain cells from damage?

Preterm birth: reducing the risk of babies dying or developing a severe lung condition using a new AI-based tool

Peanut allergy – improving the safety and effectiveness of a new treatment

X–linked lymphoproliferative disease: working towards a new cure

Long COVID: developing a new online treatment programme to address breathing difficulties and mental health problems in children and young people

Diagnosing a heart condition earlier so newborn babies can be treated faster

Epilepsy: developing a new drug treatment for a rare and debilitating form of the condition

COVID-19: exploring the impact of the pandemic on the diagnosis, treatment and outcomes of children with brain tumours

Childhood leukaemia: developing a new treatment to overcome drug resistance

Cerebral palsy: improving children’s movement through brain stimulation

Hypertrophic cardiomyopathy – improving diagnosis and monitoring of the disease in children

Congenital heart disease – predicting the outcomes of heart surgery

Improving facial reconstructive surgery for children using tissue engineering

Anaemia: understanding the causes of a rare inherited anaemia to improve its diagnosis and treatment

COVID-19 – understanding the impact of exposure to SARS-CoV-2 early in life on a child’s brain development and mental health

Cerebral palsy: investigating the effectiveness of surgery to improve walking

Preterm birth: investigating the importance of sleep cycles on brain development

Childhood leukaemia: investigating a new drug treatment

Epilepsy: searching for a new treatment for a group of rare childhood epilepsy syndromes

Preterm birth: developing immunotherapy to prevent spontaneous preterm birth

COVID-19 – understanding why children respond differently to infection compared to adults

Reducing the long-term impact of traumatic brain injury on children’s lives

Reducing the risk of preterm birth

COVID-19: Understanding SARS-CoV-2 infection in pregnant women and their babies

COVID-19 – identifying risk factors for severe disease or long-term complications in children

Vasculitis: developing a new gene therapy for a rare inherited type of blood vessel inflammation

Cerebral palsy: can regular exercise through RaceRunning improve health and mobility?

Duchenne muscular dystrophy: searching for a new drug treatment

Cerebral palsy: improving the assessment of language understanding so children can receive the support they need

Preventing infections and reducing the risk of antibiotic-resistant infections in critically ill children

Identifying risks and improving pregnancy care in childhood cancer survivors

Inflammatory bowel disease: developing a new blood test to improve diagnosis and personalise treatment for children

Diamond-Blackfan anaemia: understanding the causes to improve diagnosis and treatment of children with the condition

Searching for new ways to treat ear infections

Birth asphyxia – predicting long-term effects

Cerebral palsy: developing a new technology-based approach for hand and arm rehabilitation

Searching for treatments for three rare neurodevelopmental disorders

Autism and ADHD: using state-of-the-art brain scanning techniques to spot problems early

Can we prevent food allergies by giving young babies small amounts of the foods that cause them?

Bronchiolitis: developing ways to prevent or treat serious lung infections

Preventing brain injury in premature babies

Helping preterm babies get the best treatments to combat infection

Mitochondrial DNA depletion syndrome: developing a new treatment

Lazy eye (amblyopia): gathering hard evidence on the best way to restore children’s vision

Can special play activities help premature babies with learning?

Developing a new test to identify women at risk of premature birth

Microtia: improving surgery for children with small or missing ears

Spinal muscular atrophy: developing a potential new treatment

Cystic kidney disease – finding new drug treatments

Juvenile idiopathic arthritis: personalising drug treatment

X-linked inhibitor of apoptosis deficiency: developing a gene therapy cure for this rare disorder

Pneumococcal meningitis: saving children’s lives and reducing complications from this serious infection

Amblyopia: testing a new 3D movie treatment for lazy eye

Vision in children born to mothers taking methadone in pregnancy

Improving surgery for babies born with heart defects

Brain cancer: identifying the best treatment for each child

Preventing neural tube defects

Cystic fibrosis: protecting children from life-changing infections

Cerebral palsy: does it benefit children to stand up and exercise during lessons?

Premature birth: helping babies whose early arrival has put them at risk of future anxiety

Cystic fibrosis: developing a new type of gene therapy

Premature birth - how does breastmilk help protect vulnerable babies from illness?

Developmental language disorder: understanding the genes involved to help improve children’s lives

Epilepsy: are night-time breathing problems disrupting children’s sleep?

Niemann-Pick disease type C: testing a potential new drug treatment

Reducing the impact of congenital heart disease on brain development

Could a video game, combined with electrical brain stimulation, help children with ADHD?

What causes Crohns disease?

Charcot-Marie-Tooth disease - an inherited neurological disorder

Brain damage at birth: could a diabetes medicine be protective?

Cystic fibrosis: improving treatment for lung infections

Neuroblastoma: helping children’s immune systems to fight high-risk cancers

Could ultrasound scans help identify early hip problems for children with cerebral palsy?

Neuroblastoma: helping children who are at greatest risk from this potentially life-threatening cancer

Scarlet fever: reducing the spread of infection to help lower the risk of more serious life-threatening diseases

Head injuries: could new brain scans help guide treatment and improve children’s outlook for the future?

Perrault syndrome: working towards new treatments for children with this rare condition

Developmental coordination disorder: how do children learn new movements?

Epilepsy: a new way to treat children with uncontrolled seizures

Inflammatory bowel disease: identifying children who are most in need of intensive early treatment

Premature birth: delaying early labour

Craniosynostosis: improving treatment for children

Asthma: could personalised treatment improve children’s quality of life?

Neurodegenerative disorders with brain iron accumulation – finding new treatments

Neurofibromatosis type 1: spotting early signs of autism and ADHD in babies

Acute lymphoblastic leukaemia: making treatment even better

X-linked ichthyosis: searching for better treatments for boys with this rare skin condition

Germ cell cancers – protecting children from the side effects of treatment and saving more lives

Developmental delay and learning difficulties: spotting problems early so young children can get the help they need

Craniosynostosis: improving diagnosis and care for children with this rare condition

Juvenile Batten disease - could a widely used medicine help children with this devastating, rare condition?

Helping children in special schools to overcome vision problems

Down syndrome: the mysterious benefits of bifocal glasses

Epilepsy: could better brain scans enable more children to have life-changing surgery?

Premature birth: tackling children’s difficulties with maths at school

Systemic lupus erythematosus – helping children and teenagers understand why they are affected by this rare and disabling condition

Pelizaeus-Merzbacher disease – finding new treatments

NEC: protecting newborn babies from this life-threatening bowel problem

Developing safer tests for cystic fibrosis and spinal muscular atrophy during pregnancy

Cerebral palsy: helping severely disabled children who use their eyes to communicate

X-linked lymphoproliferative disease: a step closer to developing a cure

Primary ciliary dyskinesia: tackling the underlying cause of this debilitating, rare condition

Neurofibromatosis type 2

ADHD and autism spectrum conditions: could new brain scans improve diagnosis?

Tourette syndrome: why are some children more prone to tics?

Cerebral palsy: can exercises that strengthen calf muscles make walking easier for teenagers?

Helping children who were born with cleft palate to speak clearly

Premature birth: predicting who’s at risk

Searching for better treatments for children with a rare metabolic disease

Cerebral palsy: seizing the power of the body’s natural healing processes to repair brain damage

Tackling a rare condition that robs children of their ability to talk and understand speech: Landau Kleffner syndrome

Personalising surgery for babies with a serious heart disease

Craniopharyngiomas: developing new drug treatments for children with these devastating tumours

Anaemia – improving diagnosis and treatment for severe anaemia

Stillbirth: searching for ways to protect babies from the tragedy of being stillborn

Leukodystrophies: developing a new treatment for children with these devastating rare conditions

Pelizaeus-Merzbacher disease: developing a new way to study and eventually treat this disabling, rare disease of childhood

Pregnancy: detecting complications earlier so women can get help sooner

Could an app help tackle high levels of depression in teenagers with ADHD?

Sanfilippo type B: developing a new treatment for this rare and devastating disease

Cataracts: could a new approach to surgery improve children’s vision?

Cerebral palsy: searching for a better way to predict children’s future needs and abilities

Lysosomal storage diseases: developing new treatments for these rare and devastating diseases

Argininosuccinic aciduria: developing a new treatment for this rare disorder

HIV, immunodeficiencies and cancer: strengthening children’s immune defences

Protecting more children from meningitis by developing a new MenB vaccine

Brain damage at birth: could drug treatment help babies who need cooling therapy?

Neuroblastoma: developing a new treatment for young children with cancer

Could specially designed implants help babies with rare breathing difficulties?

ADHD: could brain-training help children gain better self-control?

Premature birth: how to stop women from going into labour too soon

Developing a new treatment for children with a rare disorder who are vulnerable to life-threatening infections

Autism spectrum disorders: monitoring children’s brain waves could allow earlier, more objective diagnosis

Severe asthma: are fungi to blame?

Head injuries: investigating the benefits of memory training

Manganese toxicity: tackling this disabling metabolic imbalance

Crohn’s disease and ulcerative colitis: how do the foods children eat affect their disease?

Helping babies who are at risk of becoming obese

Mitochondrial diseases: developing new treatments for children with these rare and sometimes devastating diseases

Autism spectrum conditions: could glasses with coloured lenses help children?

Creating new ears and noses for children who need them

Perthes’ disease: identifying who is at risk and why?

Diabetes during pregnancy: what puts babies at risk of diabetes too?

Cystic fibrosis: which babies are at highest risk of the most severe disease?

Smith-Lemli-Opitz syndrome: working towards a new treatment

Tackling drug-resistant infections in seriously ill children

Long-lasting pain: could specially designed computer games bring children much needed relief?

Bowel problems in newborns – improving diagnosis of necrotising enterocolitis

Cystic fibrosis - developing a new type of inhaled treatment

Duchenne muscular dystrophy: developing a badly needed new treatment for boys with this devastating condition

Congenital heart disease: improving treatment of babies and children born with heart defects

Cerebral palsy: how a smart phone app for pre-school children might help with rehabilitation

Premature birth: predicting which women might go into labour too soon

Epilepsy: does sleep disruption interfere with children’s learning?

Twin-twin transfusion syndrome: developing a new way to help babies who are struggling in the womb

Fetal growth restriction: new hope for babies whose growth becomes dangerously slow in the womb

Ataxias: hunting down the genetic causes of these devastating disorders of balance and coordination

Premature birth: why are premature babies at increased risk of developing ADHD?

Birth asphyxia: diagnosing fetal distress during labour

Auditory Processing Disorder: why do some children struggle to make sense of speech?

Epilepsy: new brain scans could give more children the chance of surgery

X-linked lymphoproliferative disease: developing a cure for this rare disorder

Premature birth and induced labour: boosting understanding gives new hope

Sickle cell disease: which children are at highest risk of kidney failure?

Flat feet: which children need surgery?

Down syndrome and obstructive sleep apnoea: better screening to help early diagnosis and unnecessary suffering

Oxygen deprivation at birth: could a new type of 'gas and air' relieve mothers’ labour pains and protect babies?

Blindness: how better diagnosis of a rare illness might protect children’s sight

Stillbirth and other pregnancy complications: predicting who’s at risk

Attention deficit hyperactivity disorder (ADHD): why do some children grow out of their disorder while others do not?

Brain damage in babies: could sophisticated computing allow earlier diagnosis and better care?

Brain cancer: tackling medulloblastoma, the most common, malignant, childhood brain tumour

Vitamin D deficiency: should advice on sun exposure take skin colour into account?

Pre-eclampsia: what goes wrong inside the placenta?

Jeune syndrome: why are some babies born with this rare and disabling condition?

Learning disability: finding genes, improving lives

Startle disease: hunting down elusive genes

Obesity in children: could sleep deprivation and technology use be partly to blame?

Meningitis and septicaemia – developing a new vaccine

Anxiety in children: how boosting memory might reduce anxiety and improve performance at school

Secrets of a 'superbug': what makes Pseudomonas bacteria so deadly?

What causes learning disabilities?

Bronchiolitis and RSV infection