All research projects

Brain injury at birth: could a new treatment called mitochondrial transplantation help protect brain cells from damage?

Preterm birth: reducing the risk of babies dying or developing a severe lung condition using a new AI-based tool

Peanut allergy – improving the safety and effectiveness of a new treatment

X–linked lymphoproliferative disease: working towards a new cure

Long COVID: developing a new online treatment programme to address breathing difficulties and mental health problems in children and young people

Diagnosing a heart condition earlier so newborn babies can be treated faster

Epilepsy: developing a new drug treatment for a rare and debilitating form of the condition

COVID-19: exploring the impact of the pandemic on the diagnosis, treatment and outcomes of children with brain tumours

Childhood leukaemia: developing a new treatment to overcome drug resistance

Cerebral palsy: improving children’s movement through brain stimulation

Hypertrophic cardiomyopathy – improving diagnosis and monitoring of the disease in children

Congenital heart disease – predicting the outcomes of heart surgery

Improving facial reconstructive surgery for children using tissue engineering

Anaemia: understanding the causes of a rare inherited anaemia to improve its diagnosis and treatment

COVID-19 – understanding the impact of exposure to SARS-CoV-2 early in life on a child’s brain development and mental health

Cerebral palsy: investigating the effectiveness of surgery to improve walking

Preterm birth: investigating the importance of sleep cycles on brain development

Childhood leukaemia: investigating a new drug treatment

Epilepsy: searching for a new treatment for a group of rare childhood epilepsy syndromes

Preterm birth: developing immunotherapy to prevent spontaneous preterm birth

COVID-19 – understanding why children respond differently to infection compared to adults

Reducing the long-term impact of traumatic brain injury on children’s lives

Reducing the risk of preterm birth

COVID-19: Understanding SARS-CoV-2 infection in pregnant women and their babies

COVID-19 – identifying risk factors for severe disease or long-term complications in children

Vasculitis: developing a new gene therapy for a rare inherited type of blood vessel inflammation

Cerebral palsy: can regular exercise through RaceRunning improve health and mobility?

Duchenne muscular dystrophy: searching for a new drug treatment

Cerebral palsy: improving the assessment of language understanding so children can receive the support they need

Preventing infections and reducing the risk of antibiotic-resistant infections in critically ill children

Identifying risks and improving pregnancy care in childhood cancer survivors

Inflammatory bowel disease: developing a new blood test to improve diagnosis and personalise treatment for children

Diamond-Blackfan anaemia: understanding the causes to improve diagnosis and treatment of children with the condition

Searching for new ways to treat ear infections

Birth asphyxia – predicting long-term effects

Cerebral palsy: developing a new technology-based approach for hand and arm rehabilitation

Searching for treatments for three rare neurodevelopmental disorders

Autism and ADHD: using state-of-the-art brain scanning techniques to spot problems early

Can we prevent food allergies by giving young babies small amounts of the foods that cause them?

Bronchiolitis: developing ways to prevent or treat serious lung infections

Preventing brain injury in premature babies

Helping preterm babies get the best treatments to combat infection

Mitochondrial DNA depletion syndrome: developing a new treatment

Lazy eye (amblyopia): gathering hard evidence on the best way to restore children’s vision

Can special play activities help premature babies with learning?

Developing a new test to identify women at risk of premature birth

Microtia: improving surgery for children with small or missing ears

Spinal muscular atrophy: developing a potential new treatment

Cystic kidney disease – finding new drug treatments

Juvenile idiopathic arthritis: personalising drug treatment

X-linked inhibitor of apoptosis deficiency: developing a gene therapy cure for this rare disorder

Pneumococcal meningitis: saving children’s lives and reducing complications from this serious infection

Amblyopia: testing a new 3D movie treatment for lazy eye

Vision in children born to mothers taking methadone in pregnancy

Improving surgery for babies born with heart defects

Brain cancer: identifying the best treatment for each child

Preventing neural tube defects

Cystic fibrosis: protecting children from life-changing infections

Cerebral palsy: does it benefit children to stand up and exercise during lessons?

Premature birth: helping babies whose early arrival has put them at risk of future anxiety

Cystic fibrosis: developing a new type of gene therapy

Premature birth - how does breastmilk help protect vulnerable babies from illness?

Developmental language disorder: understanding the genes involved to help improve children’s lives

Epilepsy: are night-time breathing problems disrupting children’s sleep?

Niemann-Pick disease type C: testing a potential new drug treatment

Reducing the impact of congenital heart disease on brain development

Could a video game, combined with electrical brain stimulation, help children with ADHD?

What causes Crohns disease?

Charcot-Marie-Tooth disease - an inherited neurological disorder

Brain damage at birth: could a diabetes medicine be protective?

Cystic fibrosis: improving treatment for lung infections

Neuroblastoma: helping children’s immune systems to fight high-risk cancers

Could ultrasound scans help identify early hip problems for children with cerebral palsy?

Neuroblastoma: helping children who are at greatest risk from this potentially life-threatening cancer

Scarlet fever: reducing the spread of infection to help lower the risk of more serious life-threatening diseases

Head injuries: could new brain scans help guide treatment and improve children’s outlook for the future?

Perrault syndrome: working towards new treatments for children with this rare condition

Developmental coordination disorder: how do children learn new movements?

Epilepsy: a new way to treat children with uncontrolled seizures

Inflammatory bowel disease: identifying children who are most in need of intensive early treatment

Premature birth: delaying early labour

Craniosynostosis: improving treatment for children

Asthma: could personalised treatment improve children’s quality of life?

Neurodegenerative disorders with brain iron accumulation – finding new treatments

Neurofibromatosis type 1: spotting early signs of autism and ADHD in babies

Acute lymphoblastic leukaemia: making treatment even better

X-linked ichthyosis: searching for better treatments for boys with this rare skin condition

Germ cell cancers – protecting children from the side effects of treatment and saving more lives

Developmental delay and learning difficulties: spotting problems early so young children can get the help they need

Craniosynostosis: improving diagnosis and care for children with this rare condition

Juvenile Batten disease - could a widely used medicine help children with this devastating, rare condition?

Helping children in special schools to overcome vision problems

Down syndrome: the mysterious benefits of bifocal glasses

Epilepsy: could better brain scans enable more children to have life-changing surgery?

Premature birth: tackling children’s difficulties with maths at school

Systemic lupus erythematosus – helping children and teenagers understand why they are affected by this rare and disabling condition

Pelizaeus-Merzbacher disease – finding new treatments

NEC: protecting newborn babies from this life-threatening bowel problem

Developing safer tests for cystic fibrosis and spinal muscular atrophy during pregnancy

Cerebral palsy: helping severely disabled children who use their eyes to communicate

X-linked lymphoproliferative disease: a step closer to developing a cure

Primary ciliary dyskinesia: tackling the underlying cause of this debilitating, rare condition

Neurofibromatosis type 2

ADHD and autism spectrum conditions: could new brain scans improve diagnosis?

Tourette syndrome: why are some children more prone to tics?

Cerebral palsy: can exercises that strengthen calf muscles make walking easier for teenagers?

Helping children who were born with cleft palate to speak clearly

Premature birth: predicting who’s at risk

Searching for better treatments for children with a rare metabolic disease

Cerebral palsy: seizing the power of the body’s natural healing processes to repair brain damage

Tackling a rare condition that robs children of their ability to talk and understand speech: Landau Kleffner syndrome

Personalising surgery for babies with a serious heart disease

Craniopharyngiomas: developing new drug treatments for children with these devastating tumours

Anaemia – improving diagnosis and treatment for severe anaemia

Stillbirth: searching for ways to protect babies from the tragedy of being stillborn

Leukodystrophies: developing a new treatment for children with these devastating rare conditions

Pelizaeus-Merzbacher disease: developing a new way to study and eventually treat this disabling, rare disease of childhood

Pregnancy: detecting complications earlier so women can get help sooner

Could an app help tackle high levels of depression in teenagers with ADHD?

Sanfilippo type B: developing a new treatment for this rare and devastating disease

Cataracts: could a new approach to surgery improve children’s vision?

Cerebral palsy: searching for a better way to predict children’s future needs and abilities

Lysosomal storage diseases: developing new treatments for these rare and devastating diseases

Argininosuccinic aciduria: developing a new treatment for this rare disorder

HIV, immunodeficiencies and cancer: strengthening children’s immune defences

Protecting more children from meningitis by developing a new MenB vaccine

Brain damage at birth: could drug treatment help babies who need cooling therapy?

Neuroblastoma: developing a new treatment for young children with cancer

Could specially designed implants help babies with rare breathing difficulties?

ADHD: could brain-training help children gain better self-control?

Premature birth: how to stop women from going into labour too soon

Developing a new treatment for children with a rare disorder who are vulnerable to life-threatening infections

Autism spectrum disorders: monitoring children’s brain waves could allow earlier, more objective diagnosis

Severe asthma: are fungi to blame?

Head injuries: investigating the benefits of memory training

Manganese toxicity: tackling this disabling metabolic imbalance

Crohn’s disease and ulcerative colitis: how do the foods children eat affect their disease?

Helping babies who are at risk of becoming obese

Mitochondrial diseases: developing new treatments for children with these rare and sometimes devastating diseases

Autism spectrum conditions: could glasses with coloured lenses help children?

Creating new ears and noses for children who need them

Perthes’ disease: identifying who is at risk and why?

Explore our research on Perthes Disease, focusing on risk factors and causes, with the aim of improving diagnosis and treatment outcomes for children.

Diabetes during pregnancy: what puts babies at risk of diabetes too?

Cystic fibrosis: which babies are at highest risk of the most severe disease?

Smith-Lemli-Opitz syndrome: working towards a new treatment

Tackling drug-resistant infections in seriously ill children

Long-lasting pain: could specially designed computer games bring children much needed relief?

Bowel problems in newborns – improving diagnosis of necrotising enterocolitis

Cystic fibrosis - developing a new type of inhaled treatment

Duchenne muscular dystrophy: developing a badly needed new treatment for boys with this devastating condition

Congenital heart disease: improving treatment of babies and children born with heart defects

Discover how our research aims to improve treatments for babies and children born with heart defects, offering hope for a healthier future.

Cerebral palsy: how a smart phone app for pre-school children might help with rehabilitation

Premature birth: predicting which women might go into labour too soon

Epilepsy: does sleep disruption interfere with children’s learning?

Twin-twin transfusion syndrome: developing a new way to help babies who are struggling in the womb

Fetal growth restriction: new hope for babies whose growth becomes dangerously slow in the womb

Ataxias: hunting down the genetic causes of these devastating disorders of balance and coordination

Premature birth: why are premature babies at increased risk of developing ADHD?

Birth asphyxia: diagnosing fetal distress during labour

Auditory Processing Disorder: why do some children struggle to make sense of speech?

Epilepsy: new brain scans could give more children the chance of surgery

X-linked lymphoproliferative disease: developing a cure for this rare disorder

Premature birth and induced labour: boosting understanding gives new hope

Sickle cell disease: which children are at highest risk of kidney failure?

Flat feet: which children need surgery?

Down syndrome and obstructive sleep apnoea: better screening to help early diagnosis and unnecessary suffering

Oxygen deprivation at birth: could a new type of 'gas and air' relieve mothers’ labour pains and protect babies?

Blindness: how better diagnosis of a rare illness might protect children’s sight

Stillbirth and other pregnancy complications: predicting who’s at risk

Attention deficit hyperactivity disorder (ADHD): why do some children grow out of their disorder while others do not?

Brain damage in babies: could sophisticated computing allow earlier diagnosis and better care?

Brain cancer: tackling medulloblastoma, the most common, malignant, childhood brain tumour

Vitamin D deficiency: should advice on sun exposure take skin colour into account?

Pre-eclampsia: what goes wrong inside the placenta?

Jeune syndrome: why are some babies born with this rare and disabling condition?

Learning disability: finding genes, improving lives

Startle disease: hunting down elusive genes

Obesity in children: could sleep deprivation and technology use be partly to blame?

Meningitis and septicaemia – developing a new vaccine

Anxiety in children: how boosting memory might reduce anxiety and improve performance at school

Secrets of a 'superbug': what makes Pseudomonas bacteria so deadly?

What causes learning disabilities?

Bronchiolitis and RSV infection